The iv drug compatibility chart is based on information from the handbook of injectable drugs, 16th edition, by lawrence a. Iron supplements, also known as iron salts and iron pills, are a number of iron formulations used to treat and prevent iron deficiency including iron deficiency anemia. Iron dextran is a stable, clear brown solution available in 2 and 5ml ampuls and a 10ml multipledose vial. This characteristic branching distinguishes a dextran from a dextrin, which is a straight chain glucose polymer tethered by. It is composed of approximately 95% alphad16 linkages. Iv ozone, high dose vitamin c booklet index page no. However, other methods indicate branches of greater than 50 glucose units exist. Plasma is needed to circulate red blood cells that deliver oxygen throughout the body. Compatibility considerations in parenteral nutrient solutions. Any of several watersoluble high molecular weight glucose polymers ranging between mw 1,000 and 40,000,000.
The common feature is a preponderance of 1 6linked. Dextran infusion concerned first timer healthboards. The first edition of this booklet was published in 1972. Dailymed lmd in dextrose dextran 40 injection, solution. Incompatibilities are based on meeting any of the following criteria. This medication is usually injected deep into the muscle of the buttock or slowly into a vein as directed by your doctor. Four hundred seventyone adult patients and ten adult prisoner volunteers received 2,099 intravenous iv injections of iron dextran imferon, usually 250 to 500 mg at less than 100 mgmin. Test dose, observation recommended for iron dextran. Dextran is a complex branched glucan polysaccharide derived from the condensation of glucose. Infed, dexferrum iron dextran complex dosing, indications. Compatibility of xanthan gum solutions 12 acids 12 bases 12 salts 12 thickeners. Also described as low viscous or low viscosity dextran, dextran 40 is prepared by acid hydrolysis and differential fractionation. May be given direct iv or further diluted in 50ml nsd5w.
Infed iron dextran side effects, images, uses, dosage. Dextran definition of dextran by medical dictionary. Iron dextran injection contains 50 mg of elemental iron per ml. In most cases the length of the side chains is short, and. Highmolecular weight dextran is a plasma volume expander made from natural sources of sugar glucose. Infed, iron dextran ivim, 50mgml, sdv, 2mlvial mcguff.
Dextran polymeric chains showed fast hydration kinetics with high amount of water absorbed, which turned into fast dissolution or fast swelling as a function of the molecular weight. She said it is about 20 minutes between the test dose. Nov 09, 2018 highmolecular weight dextran is a plasma volume expander made from natural sources of sugar glucose. Iron dextran vc iron sucrosea c ixabepilone ii c leucovorin cv c c1,3 i1 c1,2,3 c1 1,3 c1 c1 1 1 1,3 1 i1 c1 c1 c2 1 1,3i2 c1,3 c 1c 1c c c 1c c 1,3c 1,3c 1c 1c 1c i c c c1 c1 c1 c1 c c c levoleucovorin cc v2 c1 lorazepam vv v i 1c 1c c c1,3 c 1c c c 1c i 1c c cabazitaxel c iv compatibility guide. May 26, 2015 infed iron dextran injection usp is a dark brown, slightly viscous sterile liquid complex of ferric hydroxide and dextran for intravenous or intramuscular use. At a mean followup of 6 weeks after the administration of iv iron dextran, hemoglobin levels had significantly increased by a mean of 1.
Prior to the first therapeutic dose, administer a test dexferrum dose of 0. Always have resuscitation equipment and personnel trained in the detection and treatment of anaphylactictype reactions readily available during dexferrum adminisration. The formation of dextran in wine was shown by pasteur to be due to the activity of microbes. Infed iron dextran injection usp is a dark brown, slightly viscous sterile liquid complex of ferric hydroxide and dextran for intravenous or intramuscular use each ml contains the equivalent of 50 mg of elemental iron as an iron dextran complex, approximately 0. The molecular weight of the fraction is in most cases a key property and is defined in terms of the average molecular weight mw 2 and the number average molecular weight mn 3. Iron dextran injection is in a class of medications called iron replacement products. Dextrans are a family of highmolecularweight polymers composed of dglucose units interconnected with. It works by replenishing iron stores so that the body. It works by restoring blood plasma lost through severe bleeding. Cosmofer in a dose of 100200 mg iron 24ml may be diluted in 100 ml. In the present investigation, the data obtained are for leuconostoc mesenteroides nrrl b512 and its watersoluble dextran.
Severe blood loss can decrease oxygen levels and can lead to organ failure, brain damage, coma, and possibly death. Jul 03, 2018 iron dextran is injected into a vein through an iv. If test dose uneventful, give the remainder of the total dose as 100 mg elemental iron per day im or iv until the total calculated dose is given. Hi everyone, i am going in tomorrow for my first iron dextran infusion and i am a bit concerned after speaking to the nurse about it and reading the side effects. Iron dextran is used to treat iron deficiencies and iron deficiency anemia low red blood cells iron dextran may also be used. Bemiller, in encyclopedia of food sciences and nutrition second edition, 2003. Infed iron dextran dose, indications, adverse effects. More information is available on the fda web site any serious adverse. Intravenous iron supplies enough iron to permit rbc formation greater. Dextran net charge and fixability we employ succinimidyl coupling of our dyes to the dextran molecule, which, in most cases, results in a neutral or anionic dextran. Dec 12, 2019 lmd dextran 40 is a sterile, nonpyrogenic preparation of low molecular weight dextran average mol. Iron dextran is used to treat iron deficiencies and iron deficiency anemia low red blood cells. The structure of an individual dextran varies with the strain of microorganism. Repeat dosage of dextran 1 if more than 15 minutes elapses during infusion.
Iron deficiency easily treated with iv dextran medscape. Dextran 1 should be given just before infusing low or highmolecularweight dextran. Intravenous iron supplies enough iron to permit rbc formation greater than 50. Protocol for the use of iv iron dextran cosmofer iv iron dextran cosmofer protocol page 10 of 11 author. Miers from the starch and dextrose division, northern regional research laboratory, peoria, illinoist received for publication, june 21, 1948.
Dextran 40 definition of dextran 40 by medical dictionary. Dextran, high molecular weight side effects, dosage. For solution and drug compatibility information, see compatibility under stability. Indications and dosages prevention of severe anaphylactoid reaction caused by low or highmolecularweight dextran. Dextran definition is any of numerous glucose biopolymers of variable molecular weight that are produced especially by the fermentation of sucrose by bacteria such as genus leuconostoc, are found in dental plaque, and are used especially in blood plasma substitutes. Infed iron dextran injection usp is a dark brown, slightly viscous sterile liquid complex of ferric hydroxide and dextran for intravenous or intramuscular use. Dextran, amino, 70,000 mw thermo fisher scientific. Physical properties of dextran molecular weight and size dextran fractions are supplied in molecular weights from 1,000 daltons to 2,000,000 daltons 1. Iron dextran side effects, dosage, interactions drugs. The reaction used to produce the rhodamine green and alexa fluor 488 dextrans results in the final product being neutral, anionic, or cationic. Dextran and its potential use as tablet excipient sciencedirect. This product requires a verified medical license to purchase. The remainder of the dose may be given over the last hour of dialysis.
Ferric hydroxide 100 or ferric oxyhydroxide 101 in a complex with partially hydrolyzed low molecular weight dextran. She said that the test dose is given ad then they give the benadryl right before the treatment begins. The remaining a linkages account for the branching of dextran. We have been successfully audited by several large pharmaceutical companies from canada, usa and europe. A list of compatible smart devices for the dexcom mobile apps available in the united states and internationally. Iron dextran is injected into a vein through an iv. With a wide array of applications for our dextran based product line, we have established a loyal customer base in europe, united states, canada, the pacific rim and other locations across. Dextrans, a group of polysaccharides composed of glucose, are secreted by certain strains of bacteria as slimes. Dextran chains are of varying lengths from 3 to 2000 kilodaltons the polymer main chain consists of. Additive compatibility drugs in syringe compatibility. Prevention may also be used in low birth weight babies. Iron dextran injection is commercially available as a sterile solution of iron dextran complex containing 5% iron and 20% dextran. It contains 50 mgiml of elemental iron, most of which is present in the ferric state. Dextran is a synthetic colloid consisting of mixture of glucose polymers derived from the action of leuconostoc mesenteroides on sucrose and is currently available in 10% dextran 40 40 kda and 6% dextran 70 70 kda.
Dextran handbook introduction to dextran a comprehensive presentation of the chemical and physical properties, structure, stability, biocompatibility, and biodegradability of dextran fractions is given in the dextran handbook. The maximum iv im dose of undiluted iron dextran is 100 mg 2 ml per day. Molecular weight and size dextran fractions are supplied in molecular weights from 1,000 daltons to 2,000,000 daltons 1. Gentran, lmd dextran dosing, indications, interactions. Initially, 500 ml of a 10% solution in sodium chloride 0. Nevertheless, these results suggest other uses for dextrans in tablet formulation both in pharmaceutical and nutraceutical products. Uses for iron dextran iron deficiency not amenable to oral iron therapy. Many antibiotics are probably stable, especially when administered by coinfusion rather than by.
Cosmofer summary of product characteristics smpc emc. For prevention they are only recommended in those with poor absorption, heavy menstrual periods, pregnancy, hemodialysis, or a diet low in iron. Conflicting data on the branch lengths implies that the average branch length is less than three glucose units. Webmd provides common contraindications for dextran 40 10 % in 0. Administer 20 ml dextran 1 before administration of dextran 40.
The form infed elemental iron, 50 mgml, low molecular iron is given both iv and im, while the form dexferrum elemental iron, 50 mgml, high molecular iron dextran is given only iv and is administered slowly. Find out what health conditions may be a health risk when taken with dextran 40 10 % in 0. Maintenance2575 mcgkgmin infusion or incremental bolusesof1020mg. On each occasion the first 25 mg of iron should be infused over a period of 15 minutes. Dextran is a generic term for a family of glucans made by polymerization of the.
Protocol for the use of iv iron dextran cosmofer iv iron dextran cosmofer protocol page 7 of 11 author. Dexferrum iron dextran injection, usp rx only warning. Precipitation of calcium phosphate when calcium and phosphate salts are added can be affected by ph, amino acid concentration, amino acid. Jul 03, 2018 infed iron dextran injection usp is a dark brown, slightly viscous sterile liquid complex of ferric hydroxide and dextran for intravenous or intramuscular use. Do not selfinject this medicine if you do not understand how to give the injection and properly dispose of used needles, iv tubing, and other items used to inject the medicine. Treatment of iron deficiency when oral iron preparations are ineffective or cannot be used. Historically, dextrans had been long recognized as contaminants in sugar processing and other food production. Each ml contains the equivalent of 50 mg of elemental iron as an iron dextran complex, approximately 0.
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